Indiana University school of medicine researchers used a changed lentivirus to introduce a potent anti-melanoma T cell receptor gene into the hematopoietic stem cells of mice. Hematopoietic stem cells are the cells that give rise to  all blood and immune system cells.

The T cell gene, that recognizes a particular protein found on the surface of melanoma, was isolated and cloned from a patient with melanoma. The gene-modified stems cells were  transplanted back to hosts and found to eradicate metastatic melanoma for the lifetime of the animals.

1. Do what you love. Jobs once said, "People with passion can change the world for the better." Asked about the advice he would offer would-be entrepreneurs, he said, "I'd get a job as a busboy or something until I figured out what I was really passionate about." That's how much it meant to him. Passion is everything.

2. Put a dent in the universe. Jobs believed in the power of vision. He once asked then-Pepsi President, John Sculley, "Do you want to spend your life selling sugar water or do you want to change the world?" Don't lose sight of the big vision.

ScienceDaily (Oct. 13, 2011) — For the first time, scientists have cleanly corrected a human gene mutation in a patient's stem cells. The result, reported Oct. 12 in the journal Nature, brings the possibility of patient-specific therapies closer to becoming a reality.

ScienceDaily (June 27, 2011) — Using an innovative gene therapy technique called genome editing that hones in on the precise location of mutated DNA, scientists have treated the blood clotting disorder hemophilia in mice. This is the first time that genome editing, which precisely targets and repairs a genetic defect, has been done in a living animal and achieved clinically meaningful results.